Organising pneumonia Pathology outlines

Pneumonia may resolve or organize. Organizing pneumonia may simulate malignancy due to radiographic shadows and clinical cough, hemoptysis and weight loss. May also simulate TB ( Pathol Int 2011;61:486 ) Usually due to Streptococcus pneumoniae or Haemophilus influenza cryptogenic organizing pneumonia, transplant rejection, infection ( pneumonia ), collagen vascular disease, peri-tumour. Treatment. dependent on underlying cause. Organizing pneumonia, abbreviated OP, is a histologic pattern in lung pathology. It fits into the larger category of diffuse lung diseases Diagnostic Criteria. Organizing pneumonia (BOOP) is a pattern that has many causes including. Infection, toxins, drugs, radiation, inflammatory bowel disease. May present associated with connective tissue disease. When idiopathic, it is termed cryptogenic organizing pneumonia (COP) Clinical. Subacute onset of dyspnea, cough Organising pneumonia is the pathological hallmark of a distinct type of lung injury and repair rather than a disease with one defined aetiology. The histopathophysiology underlying organising pneumonia can be seen as a blueprint of a pulmonary type of wound healing that results in a serious lung disorder.144 14

Organising pneumonia (otherwise referred to as bronchiolitis obliterans organising pneumonia) is characterised histologically by plugs of granulation tissue, which are present predominantly within small airways, alveolar ducts and peri-bronchiolar alveoli Organizing pneumonia refers to organized swirls of inflammatory tissue filling the small spherical units of the lungs referred to as alveoli and the alveolar ducts. Individuals with BOOP experience inflammation of the bronchioles and alveolar lung spherical units simultaneously, which distinguishes it from other similar inflammatory lung disorders Cryptogenic organizing pneumonia, formerly known as bronchiolitis obliterans organizing pneumonia, is an inflammation of the bronchioles and surrounding tissue in the lungs. It is a form of idiopathic interstitial pneumonia. It is often a complication of an existing chronic inflammatory disease such as rheumatoid arthritis, dermatomyositis, or it can be a side effect of certain medications such as amiodarone. COP was first described by Gary Epler in 1985. The clinical features and.

Organizing pneumonia (OP) is a histologic term characterized by patchy filling of alveoli and bronchioles by loose plugs of connective tissue. OP may be an incidental finding in lung biopsy specimens or may be found nearby areas of lung involved by other diseases. On other occasions, OP may be the p Cryptogenic organizing pneumonia (COP), the idiopathic form of organizing pneumonia (formerly called bronchiolitis obliterans organizing pneumonia or BOOP), is a type of diffuse interstitial lung disease that affects the distal bronchioles, respiratory bronchioles, alveolar ducts, and alveolar walls [ 1-7 ]. The primary area of injury is within. Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organ . Organising pneumonia is defined. PURPOSE: To describe the appearance and frequency of a perilobular pattern at thin-section computed tomography (CT) in patients with organizing pneumonia. MATERIALS AND METHODS: Thin-section CT scans of 21 consecutive patients with cryptogenic organizing pneumonia were retrospectively reviewed. Two thoracic radiologists in consensus recorded the.

Pathology Outlines - Organizing pneumoni

Cryptogenic organizing pneumonia (COP), a form of idiopathic interstitial pneumonia, affects men and women equally, usually in their 40s or 50s. Cigarette smoking does not seem to be a risk factor. About one half of patients recall having an illness that resembled community-acquired pneumonia (ie, a nonresolving flu-like illness characterized. Cryptogenic Organizing Pneumonia (COP) Cryptogenic organizing pneumonia (COP) is a rare lung condition affecting the small airways (bronchioles) and alveoli (tiny air sacs). It was previously known as idiopathic bronchiolitis obliterans with organizing pneumonia (BOOP) Breast cancer and organising pneumonia: the importance of correlating thepathological findings with the clinical and radiological picture. Griffiths P(1), Doran H(2), Fullerton D(1). Author information: (1)Department of Respiratory Medicine, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, UK. (2)Department of Pathology, University Hospital of. Histopathology of aspiration pneumonia not associated with food or other particulate matter: a clinicopathologic study of 10 cases diagnosed on biopsy. Aspiration pneumonia most often presents in surgical lung biopsies as a granulomatous pneumonia with acute inflammation, microabscesses, and a granulomatous reaction to food or other particulate. The few pathological analyses of coronavirus disease (COVID-19) pneumonia to date, mostly from autopsy studies, report diffuse alveolar damage or acute fibrinous and organizing pneumonia (1-3). In contrast, computed tomographic (CT) imaging from numerous patients with COVID-19 includes features more consistent with organizing pneumonia (OP) ( 4 , 5 )

Cryptogenic organising pneumonia | Image | Radiopaedia

Organizing pneumonia pattern may be superimposed on a chronic process such as UIP in the setting of an acute Stanford Medicine » School of Medicine » Departments » Surgical Pathology Criteria » Cryptogenic Organizing Pneumonia - Bronchiolitis Obliterans Organizing Pneumonia (BOOP) Surgical Pathology Criteria . Diagnostic Criteria. Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD. Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage. Arch Pathol Lab Med. 2002 Sep;126(9):1064-70. Printed from Surgical Pathology Criteria:.

Aims Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity where non-necrotising granulomata are intimately associated with the. Multifocal lymphohistiocytic interstitial pneumonia and prominent lymphoid perivascular cuffs were observed between week 7 and 10. GMS staining confirmed the presence of Pneumocystis cysts. Thus, the results of the present study demonstrated that P. carinii caused lymphohistiocytic interstitial pneumonia in a group of laboratory rats

Organizing pneumonia may be present; Known causes must be ruled out. Drugs including antibiotics, non-steroidal anti-inflammatory, anti-hypertensive, heroin, cocaine; Organisms including fungi and parasites Allergic bronchopulmonary aspergillosis; Gerald J Berry MD Robert V Rouse MD Department of Pathology PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, book

Video: Organizing pneumonia - Libre Patholog

Cryptogenic Organizing Pneumonia - Surgical Pathology Criteri

From the Radiologic Pathology Archives: Organization and Fibrosis as a Response to Lung Injury in Diffuse Alveolar Damage, Organizing Pneumonia, and Acute Fibrinous and Organizing Pneumonia. Seth J. Kligerman, Teri J. Franks, Jeffrey R. Galvin; Seth J. Kligerman , Teri J. Franks, Jeffrey R. Galvi Nonspecific Interstitial Pneumonia Definition. Idiopathic interstitial lung injury demonstrating temporal uniformity and lacking diagnostic features of other diseases; Alternate/Historical Names. Department of Pathology Stanford University School of Medicine Stanford CA 94305-5342 . Original posting/updates: 11/20/1 Organizing pneumonia is a common manifestation of acute or subacute lung injury that may represent a primary pathologic abnormality or instead be secondary to a variety of underlying conditions. Determining the significance of organizing pneumonia in small, closed lung biopsies is therefore entirely dependent on the clinical context and other supportive laboratory and radiological data organising pneumonia (OP) or its histological variant, acute fibrinous and organising pneumonia, both well- known complications of viral infections. Further, many publications on COVID-19 have debated the puzzling clinical characteristics of 'silent hypoxemia', 'happy hypoxemics' and 'atypical ARDS', all features consistent with OP Keywords: Cryptogenic organising pneumonia, diagnosis, prognosis Introduction Organising pneumonia (OP) is a nonspecific response to lung injury. Buds of granulation tis - sue within the lumen of distal pulmonary air-spaces is a characteristic pathological pattern [1]. It can be secondary or cryptogenic (i.e., idio - pathic)

Reviews of COVID-19 CT imaging along with postmortem lung biopsies and autopsies indicate that the majority of patients with COVID-19 pulmonary involvement have secondary organising pneumonia (OP) or its histological variant, acute fibrinous and organising pneumonia, both well-known complications of viral infections. Further, many publications on COVID-19 have debated the puzzling clinical. Breast cancer and organising pneumonia: the importance of correlating the pathological findings with the clinical and radiological picture. Griffiths P(1), Doran H(2), Fullerton D(1). Author information: (1)Department of Respiratory Medicine, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, UK Idiopathic pulmonary fibrosis/usual pneumonia pattern. IPF is the most important and common form of chronic intersti-tial lung disease (ILD). As described in the 2002 statement, the pathology of IPF is that of usual interstitial pneumonia (UIP). 2 The term UIP was originally introduced by Liebow and Car-rington, Get a comprehensive overview of Cryptogenic Organising Pneumonia formerly known as Bronchiolitis Obliterans Organizing Pneumonia. This topic includes: What i.. Pneumonia, inflammation and consolidation of the lung tissue as a result of infection, inhalation of foreign particles, or irradiation. Many organisms, including viruses and fungi, can cause pneumonia, but the most common causes are bacteria, in particular species of Streptococcus and Mycoplasma

The COVID-19 pandemic dramatically changed medical care. Healthcare professionals are faced with new issues. Patients who survived COVID-19 have plenty of different continuing symptoms, of which the most common are fatigue and breathlessness. It is not well known how to care for patients with persistent or worsening respiratory symptoms and changes on chest X-ray following COVID-19 pneumonia The pathophysiology of pneumococcal pneumonia is informative in both treatment strategy and in vaccine design. organised inflammatory debris, bacterial DNA and cellular debris Organising pneumonia, previously called bronchiolitis obliterans organising pneumonia is a clinicopathological entity of unknown aetiology, which has been reported with increasing frequency Mucormycosis pathology. Figure 1. Figure 2. Special studies for mucormycosis. Mucormycosis organisms may easily be seen on haematoxylin and eosin sections (figure 1). Special stains with PAS (figure 2) or GMS can be used to highlight the organisms and allow a clearer assessment of the morphology

Organizing pneumonia (OP) refers to a clinicopathological entity which is associated with non-specific clinical findings, radiographic findings, and pulmonary function test (PFT) results. When an underlying cause is unknown it is classified as cryptogenic organizing pneumonia (COP; also referred to as primary organizing pneumonia) whereas if a cause is known it is then termed a secondary. typical pathological findings of organizing pneumonia and the lack of any identified cause. Therefore, the following causes of organizing pneumonia must be carefully excluded before concluding that organizing pneumonia is cryptogenic. Organizing pneumonia of determined cause Infection is a common cause of organizing pneumonia (table 1)

An inflammatory disorder involving both the peripheral bronchioles and alveoli simultaneously. It has distinctive radiographic findings, histological features, and response to corticosteroids (unlike usual interstitial pneumonia). Most common type is idiopathic BOOP; other types include focal nod.. Bronchopneumonia (Lobular pneumonia) is an acute exudative suppurative inflammation of the lungs characterized by foci of consolidation surrounded by normal parenchyma. Generally, it is produced by bacteria : staphylococcus, streptococcus, Haemophilus influenzae, proteus, Escherichia coli. Figure 1. Bronchopneumonia affects one or more lobes. Pneumonia is a common med-surg nursing disorder that you must know about in nursing school. It's important for you to understand the pathophysiology of pneumonia, it's signs and symptoms, what you need to assess for, and what nursing interventions you'll need to do for it

Organising pneumonia Thora

  1. Objective . To study the clinical and pathological characteristics of patients with organized hematoma with malignant features in maxillary sinuses. Subjects and Methods . This was a retrospective study of five patients who were treated surgically for organized hematoma. The preoperative CT and MRI findings were studied clinically
  2. Introduction. Pneumonia is the most frequent infectious disease worldwide, causing a tremendous socioeconomic burden in industrialised countries [].In addition, pneumonia is the leading infectious cause of death in children worldwide, accounting for 15% of all deaths of children under the age of 5 years [].Concerns arise from the increasing frequency of antibiotic-resistant bacteria and new.
  3. A chest X-ray can be used to diagnose pneumonia in patients. Organizing pneumonia is characterized by the way in which the lungs and airways recover from the influenza-like infection.In other types of pneumonia, dead cells accumulate into blobs of mucus and dead tissue, which are then coughed out or reabsorbed by the body
  4. Idiopathic bronchiolitis obliterans organising pneumonia (BOOP) is an uncommon but well-recognised condition that usually presents radiologically as bilateral multifocal patchy areas of consolidation on the chest radiograph and on computed tomography (CT). Five cases are described in which the presenting feature was that of a solitary pulmonary nodule. Four of these nodules showed evidence of.

Fibrosing organising pneumonia Journal of Clinical Patholog

Cryptogenic organizing pneumonia (COP) is a form of idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). Signs and symptoms may include flu-like symptoms such as cough, fever, malaise, fatigue and weight loss.COP often affects adults in midlife (40 to 60 years of age) Bronchopneumonia is a subtype of pneumonia.It is the acute inflammation of the bronchi, accompanied by inflamed patches in the nearby lobules of the lungs.. It is often contrasted with lobar pneumonia; but, in clinical practice, the types are difficult to apply, as the patterns usually overlap. Bronchopneumonia (lobular) often leads to lobar pneumonia as the infection progresses

Bronchiolitis Obliterans Organizing Pneumonia - NORD

  1. Cryptogenic organising pneumonia (COP) is a rare lung condition and a type of interstitial lung disease . It's sometimes called bronchiolitis obliterans organising pneumonia (BOOP). COP causes inflammation and scarring in the small airways and air sacs in your lungs. On this page, we cover what causes COP, what the symptoms of cryptogenic.
  2. Sarah Kay Moll Date: February 25, 2021 Ventilator-associated pneumonia is a severe lung infection in a patient who has been on a ventilator for more than 48 hours.. The pathology of pneumonia is caused by an infection in the lungs. This infection can be bacterial, viral, or fungal, and it often starts out as a complication of the flu
  3. Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of.

Cryptogenic organizing pneumonia - Wikipedi

  1. Answer From Teng Moua, M.D. Previously called bronchiolitis obliterans with organizing pneumonia, cryptogenic organizing pneumonia (COP) is a rare lung condition in which the small airways (bronchioles), the tiny air-exchange sacs (alveoli) and the walls of small bronchi become inflamed and plugged with connective tissue. The condition is.
  2. The infectious pulmonary process that occurs after abnormal entry of fluids into the lower respiratory tract is termed aspiration pneumonia. The aspirated fluid can be oropharyngeal secretions, particulate matter, or can also be gastric content. The term aspiration pneumonitis refers to inhalational acute lung injury that occurs after aspiration of sterile gastric contents
  3. This is a gross photograph of the lungs from a patient (not the patient from this case) with acute lobar pneumonia.The lung lobe in the upper-right portion of the photograph is affected with pneumonia (arrows). It has a whitish discoloration and appears swollen compared to the more pink-staining normal lung lobe in the lower right and left-hand portions of this photograph
  4. iscent of NSIP. 1
  5. Cryptogenic Organizing Pneumonia (COP) often begins with flu-like symptoms and is usually diagnosed by ruling out other diseases. Treatment is usually effective if followed strictly. Skip to main content. Everyone 12 years of age and older is now eligible to get a COVID-19 vaccination
  6. ant finding histologically are reviewed. Lesions discussed include neoplasms of histiocytes and nonneoplastic processes. The nonneoplastic processes are divided into those that present as.

Organizing pneumonia - PubMe

DEFINITION. Hospital-acquired pneumonia (HAP), or nosocomial pneumonia (NP) has been defined 1, 2 as pneumonia that develops 48 h or more after admission to a hospital and does not include pneumonia that a patient had contracted when admitted or before being admitted. However, care should be exercised in diagnosing pneumonia caused by Legionella pneumoniae as HAP if the patient develops it. Pneumonitis is more common with anti-PD-1 compared to anti-PD-1L therapies and occurs more frequently in combination immunotherapy. Pembrolizumab is associated with several patterns of lung injury including bronchiolitis, hypersensitivity pneumonitis, nonspecific interstitial pneumonia and organizing pneumonia probable pneumonia (as defined above). Table 3. Pneumonia case definitions The purpose of detailing these clinical case defi nitions is to contrast them with the morbid anatomical features of sepsis, which are less well depicted. Pathologists can assist clinical colleagues in evaluating patients dying of known or suspected sepsis, proving sepsis o Cryptogenic organizing pneumonia (COP), previously known as bronchiolitis obliterans with organizing pneumonia (BOOP), is a rare interstitial lung disease.It is a form of pneumonia in which the bronchioles (small airways), the alveoli (tiny air-exchange sacs), and the walls of the small bronchi become inflamed.. The condition is cryptogenic because the cause is unknown, and organizing.


  1. Permissions. Article. March 1961. The Pathology of Neonatal Pneumonia. JAY BERNSTEIN, M.D.; JOY WANG, M.D. Author Affiliations. DETROIT. From the Department of Pathology, Children's Hospital of Michigan, and the Departments of Pathology and Pediatrics, Wayne State University College of Medicine
  2. Pathophysiology. Aspiration causes an inflammatory reaction called pneumonitis. This can result in damage to the lung parenchyma. Damage to lung parenchyma causes an inflammatory reaction that can lead to symptoms such as fever, cough, or elevation of white cell count. A secondary bacterial infection can occur because of this damaged parenchyma.
  3. Pathology articles covering symptoms, diagnosis, staging, treatment, prognosis, and follow-up. Peer reviewed and up-to-date recommendations written by leading experts
  4. ant form of diffuse lung injury originally described by Hamman and Rich in 1935 [ 1,2 ]. AIP is classified as an idiopathic interstitial pneumonia (IIP), and among the IIPs, it has the most acute onset and rapidly progressive course [ 1-3 ]. AIP is similar in presentation to the acute.
  5. ent numbers of eosinophils.Distinguishing the histologic pattern of eosinophilic pneumonia from clinical syndromes that also contain the term eosinophilic pneumonia (eg, chronic eosinophilic pneumonia.
  6. In aspiration pneumonia, an infiltrate develops in a patient at increased risk of oropharyngeal aspiration. This occurs when a patient inhales material from the oropharynx that is colonized by.
  7. based—the pathophysiology and pathogenesis of asthma, and the natural history of asthma. Definition of Asthma Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness, and an underlying inflammation (box 2-1)

Cryptogenic Organising Pneumonia - PubMe

Relapsing bronchiolitis obliterans organising pneumonia and chronic sarcoidosis in an atopic asthmatic patient C. Carbonelli, A. Roggeri, A. Cavazza, M. Zompatori, L. Zucchi; Affiliations C. Carbonelli Department of Respiratory Diseases, Hospital Santa Maria Nuova, Reggio. Pneumonia is inflammation of the lungs with consolidation or interstitial lung infiltrates, most often categorised according to the causative organism. Typical symptoms might include fever, cough, dyspnoea, and chest pain. Because each specific type of pneumonia may result from a different aetiol.. Introduction: Localised organising pneumonia, radiologically presented with oval or round shadows mimicing lung cancer or metastases, is a major issue in differential diagnosis

Organizing Pneumonia: Perilobular Pattern at Thin-Section

Tutorial contains images and text for pathology education A closer view of the lobar pneumonia demonstrates the distinct difference between the upper lobe and the consolidated lower lobe. Radiographically, areas of consolidation appear as infiltrates Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed. This is a lobar pneumonia in which consolidation of the entire left upper lobe has occurred. This pattern is much less common than the bronchopneumonia pattern. In part, this is due to the fact that most lobar pneumonias are due to Streptococcus pneumoniae (pneumococcus) and for decades, these have responded well to penicillin therapy so that advanced, severe cases are not seen as frequently

From the radiologic pathology archives: organization and

Left, Histopathologic analysis of lung tissue from an infant with pneumonia due to rhinovirus shows thickening of the alveolar septum, hyperplasia of the alveolar lining cells, and macrophages in the alveoli (hematoxylin-eosin stain; original magnification, ×350).Right, Analysis of hyperimmune serum (by means of the modified avidin-biotin peroxidase complex method) reveals localization of. Pathology of usual interstitial pneumonia. Low power of the section demonstrates patchy interstitial fibrosis with juxtaposed relatively preserved lung tissue, resulting in architectural distortion and focal honeycomb change (hematoxylin and eosin stain, 40x original magnification)

Severe organising pneumonia following COVID-19 Thora

  1. Immune-related (IR)-pneumonitis is a rare and potentially fatal toxicity of anti-PD(L)1 immunotherapy. Expert guidelines for the diagnosis and management of IR-pneumonitis include multidisciplinary input from medical oncology, pulmonary medicine, infectious disease, and radiology specialists. Severe acute respiratory syndrome coronavirus 2 is a recently recognized respiratory virus that is.
  2. Hypersensitivity Pneumonitis Collagen Vascular Disease Familial Interstitial Pneumonia It outlines advances in the past decade and potential areas for future investigation. ogists, 4 radiologists, 5 pathologists, 2 experts in evidence-based medicine, and 4 molecular biologists). Several meetings wer
  3. Chronic obstructive pulmonary disease (COPD) affects the lungs and your ability to breathe. Get more information here on COPD pathophysiology, or the physical changes associated with the disease
  4. In pathology, honeycomb lung refers to the characteristic appearance of variably sized cysts in a background of densely scarred lung tissue. Microscopically, enlarged airspaces surrounded by fibrosis with hyperplastic or bronchiolar type epithelium are present. [] However, these changes are nonspecific and are often seen in numerous end-stage interstitial lung diseases (ILDs). [
  5. Trichinosis, disorder resulting from infestation with the small roundworm Trichinella spiralis, commonly acquired by humans by the eating of undercooked pork containing encapsulated larvae of the parasite. In the stomach and small intestine, the capsular coating is digested, and the liberate
  6. ent systemic manifestations and some respiratory symptoms. This infection, caused by Chlamydia psittaci, is transmitted to humans predo

Lipoid pneumonia is uncommon and, although it is difficult to determine the precise clinical incidence, autopsy series have reported a frequency of only 1.0-2.5% [].However, it is important to be aware of the various radiologic manifestations of lipoid pneumonia because, in the appropriate clinical setting, these findings can be diagnostic Psittacosis, infectious disease of worldwide distribution caused by a bacterial parasite (Chlamydia psittaci) and transmitted to humans from various birds. The infection has been found in about 70 different species of birds; parrots and parakeets (Psittacidae, from which the disease is named) Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of respiratory diseases affecting the interstitium (the tissue and space around the alveoli (air sacs)) of the lungs. It concerns alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. It may occur when an injury to the lungs triggers an abnormal. Imaging and clinical manifestations of viral pneumonia are not reliably predictive of its origin. Herein, emphasis was placed on the commonest imaging features of some of the most common viruses that produce pulmonary disease. Thin-section CT is an effective diagnostic method when findings at chest radiography are normal or inconclusive Nitrofurantoin is an antibacterial agent frequently used in the management of urinary tract infections (UTIs). This antimicrobial drug is generally used for treatment of acute cystitis and for prophylaxis in patients with recurrent UTIs. Pulmonary toxicity due to nitrofurantoin has two main presentations: an acute onset approximately nine days.

Bronchiolitis Obliterans Organizing Pneumonia Pulmonary

Histopathology of aspiration pneumonia not associated with

Challenges in pulmonary fibrosis · 1: Use of high

Histopathology of Pneumocystis carinii pneumonia in

Cryptogenic organizing pneumonia - The Clinical AdvisorOrganizing pneumonia/non-specific interstitial pneumonia
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